Yes it's possible. You'd use something like -
Sprite on clicked > Goto Layout (by name) > and then in the box use "Layout "&round(random(0,10))
Or if you have changed your Layout names to something specific to your game, such as level names you could use the "choose" expression so:
Sprite on clicked > Goto Layout (by name) > and then in the box use choose(emerald hills,underwater caverns,the end,the nether) this will randomly pick 1 value from the comma separated list.
It just depends on how you have named your Layouts.