I've never experienced this. I use Chrome for 99% of my testing (I know, that's probably not a good idea), and this hasn't come up for me before.
So it could mean your Chrome is out-of-date, or there's some weird bug/incompatibility in your game, or there's an actual bug in C2 or Chrome.
Could you post your capx, or attempt to replicate the issue with a simplified example?