dhondon When I think about it a little more you will have to do some scaling anyway, else you will not get to any fullscreen other than the resolution you designed. For example you do a 1024x768 project size for an ipad2, you will have to use scaling (either up or downscale) to get a fullscreen display when switching to devices that have a different native screen resolution (on an ipad3 it would be an upscale by 2).
If you decide to work on a project that supports ipad3 (2048x1536 resolution) you will most certainly get to a point where you have to reduce texture sizes and scale up your images.The ipad3 performs pretty poor with it's highres screen and high definition images eat up a lot of memory. For the sake of performance you should keep your working resolution as low as possible :)
rock on,
Michael