I'm hoping someone can confirm this for me.
My suspicion is that the very nice collision cells optimization might not work when using the "Mouse is over object" condition. Provided that this is the first condition that picks an instance of the object of course.
If this is the case, I can work around it by using a dummy object on the mouse I'm sure, and I'll start work on testing that out right now, but this would save me some time if anyone knew off-hand.
Also, if anyone knows if the system condition "Pick overlapping point" works with collision cells, that would be excellent.