Yes you can, using the greenworks plugin. That thread is completely messy though, and no one knows for sure how to get it to work sometimes. Ashley is holding off an update until a proper release of the new NW which will (hopefully) have less problems with hiccups.
You have to use Node-Webkit 0.10.x if you want it to run well and use the greenworks plugin. You can do so by either looking around in that thread or installing a old version of C2 that came bundled with it, then you just have to replace the files in the NW 0.12.x folder. After that you can install and try the plugin.
Also you cannot preview while using the plugin, you'll have to export your game to try it out. Also read that threads first post to see the instructions, the .txt part is important.