I have the same bug.
I just updated to the latest r12.2 while I was working on a project.
When I selected a sprite, all sprites and tiled background become invisible, as if the opacity is 0.
I can still select them on the layer but can't see them.
The only plugin I have are the standard ones and iap from cramberrygames and admob.
I have reverted back to r12 but the problem persist. Perhaps the file saved now as corrupted parameters.