Depending on circumstances I suppose.
If the animation is equal mirrored, then it would save memory space to use mirroring.
But if your image is not equal, say, a character carries a shield in his right and a sword in his left, when mirrored, the weapon and shield would seem switched. (being in the other hands)
In cases where size matters, and the animation frames are big, then it could save space to have things mirrored, disregarding mirroring effects.