Hi Jim15,
I'll let Lucid answer in more technical details, but:
The whole point of Spriter is to not only let artists make highly optimized animations as quickly and easily as possible, to but to also allow artists and game designers to have very natural, visual ways to control other aspects of game play... This is why it allows for the placement of multiple "action points", collision rectangles, sound effects, and variable changes at any given frame of an animation.
It is meant to be the dream tool(one of them...I'm planning on a level editor as well) for 2d game makers.
Short answer to game engine implimentation, YES, with Lucid's Spriter plug-in for Construct (and eventually Construct 2) ALL variable changes, action points, sounds, and collision rectangles AND Character maps will be super easy to detect and manipulate within Construct!
Similar plug-ins to FULLY Support Spriter files are being worked on (but are not as far along) for Unity3d, Torque 2d and at least one other game authoring system at this time.
Thanks again for your support to all of you who have already purchased the current version of Spriter :)
Please help spread the word, because the more sucessful Spriter becomes, the more agressively we can evolve it AND begin work on the Level Editor. (Similar dreamy goodness as Spriter, but for designing levels...and with complete Spriter support as well of course ;) )