Ok, looks like I found out why this was happening for me. Turns out I wasn't using 'trigger once' to call the tween and, as it was being called through a state machine, it was causing the game to freeze on layout transition. Prior to 164.2, this wouldn't have caused a crash, and as the tween looked like it was working as intended I didn't notice, but something changed in this version that causes the game to crash if it's not in a trigger once event.
I mean, I'm not sure that it's a bug as I feel we should have been doing this already, and once I found why it was happening, it was easy enough to fix.