Thanks guys, appreciate the feedback. Note, for mobile there is no suitable wrapper - I have to use crop mode with a large background, anchor key elements such as buttons and HUD, and then use my own scaling algorithm for the center game elemnts. Letterbox scaling black bars, especially in landscape where most of the screen becomes black, are not an option.
Separate portrait and landscape layouts are a must have, as the buttons possitions and other items have to move from the bottom to the side.
Ashley, how can this be done on one layout? My strategy is that I design for iphone4, then scale layers up or down or not depening on the target platform (e.g. for ipad 2 I dont scale - I use iphone 4 layout as ipad is fatter), and make sure the backgroupd image is large enought (i.e. 1024). For PC i disable the scaling, and export as fixed size and layout.
If portrait and landscape have differnt item anchor points, I dont think this can be done with a single layout?
Also, I have to have swipe left and right for settings and info. I have managed to get a prototype of this using a fixed layout 3x the window size, but this wont work if the target device has different resolution so Im still trying to figure this one out.