Correct me if I'm wrong but I think the biggest problem would be the inability to control the number of draw calls. Which doesn't matter for any game type except this one.
Let's say for example; You have a map with 100,000 tiles. Since you're at the very top of the map, only 50 tiles are showing. No problem, Construct only draws the 50 tiles that are showing but doesn't draw the remaining 99,950 tiles that are outside the visible screen.
The problem is, Construct has to loop through all 100,000 tiles to determine if they're in the visible screen and looping through 100,000 tiles each tick is expensive.
Being able to control the draw calls mean you can limit the check loop to only loop through the maximum number of instances visibly possible on the screen at any given time.
Is my thinking correct here?